protein

RAB8A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB8A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

44Outgoing

20Incoming

0Experiments

0Debates

Summary

Page for RAB8A — RAB8A Protein (Ras-Related Protein)

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🔬 Protein Info

Gene Symbol	RAB8A
Full Name	RAB8A, Member RAS Oncogene Family
Aliases	Ras-Related Protein
Chromosome	19p13.2
Function	RAB8A encodes a member of the Rab GTPase family, which are key regulators of intracellular vesicle trafficking
Molecular Weight	24 kDa
Pathways	Cholesterol
UniProt ID	P61006
NCBI Gene ID	51528
Ensembl ID	ENSG00000135569
OMIM	608030
GeneCards	RAB8A
Human Protein Atlas	RAB8A
Associated Diseases	neurodegeneration
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, C9ORF72, C9Orf72-Smcr8
KG Connections	59 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAB8A — AlphaFold P61006 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RAB8A — RAB8A, Member RAS Oncogene Family

gene · 614 words

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RAB8A — RAB8A Protein (Ras-Related Protein)

protein · 944 words

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Pathway Diagram

graph TD
    RAB8A["RAB8A"]
    Parkinson{"Parkinson"}
    RAB8A -->|"inhibits"| Parkinson
    Ms{"Ms"}
    RAB8A -->|"inhibits"| Ms
    Als{"Als"}
    RAB8A -->|"therapeutic target"| Als
    RAB8A -->|"interacts with"| Ms
    NPC1["NPC1"]
    RAB8A -->|"inhibits"| NPC1
    Cholesterol(["Cholesterol"])
    RAB8A -->|"regulates"| Cholesterol
    CANX["CANX"]
    RAB8A -->|"therapeutic target"| CANX
    HSPA5["HSPA5"]
    RAB8A -->|"therapeutic target"| HSPA5
    neurodegeneration["neurodegeneration"]
    RAB8A -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"inhibits"| RAB8A
    LRRK2["LRRK2"]
    LRRK2 -->|"regulates"| RAB8A
    RAB7A["RAB7A"]
    RAB7A -->|"therapeutic target"| RAB8A
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| RAB8A
    IGF2R["IGF2R"]
    IGF2R -->|"therapeutic target"| RAB8A
    CAPZB["CAPZB"]
    CAPZB -->|"therapeutic target"| RAB8A
    RAB5A["RAB5A"]
    RAB5A -->|"therapeutic target"| RAB8A
    HSPA1A["HSPA1A"]
    HSPA1A -->|"therapeutic target"| RAB8A
    style RAB8A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (44)

Target	Relation	Type	Str
lipid droplet-mitochondrion interaction	promotes	process	0.95
PLIN5	binds_to	protein	0.90
exercise endurance	regulates	phenotype	0.85
Autophagy	regulates	process	0.85
autophagy pathway	participates_in	pathway	0.70
Als	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	regulates	disease	0.65
Parkinson	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Ftd	inhibits	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
DNAJC5	regulates	gene	0.60
ATG7	regulates	gene	0.60
VAMP7	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
RAB27A	regulates	gene	0.60
SNAP23	inhibits	gene	0.60
STX4	inhibits	gene	0.60
SNAP23	activates	gene	0.60
ALS	regulates	gene	0.60
STX4	activates	gene	0.60
AND	regulates	gene	0.60
RAB11A	regulates	gene	0.60
App	inhibits	protein	0.60
LRRK2	regulates	gene	0.60
NPC1	regulates	gene	0.60
SMCR8	inhibits	gene	0.60
C9ORF72	inhibits	gene	0.60
ALS	inhibits	gene	0.60
HSPA5	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
CANX	therapeutic_target	gene	0.60
Cholesterol	regulates	pathway	0.60
AND	inhibits	gene	0.60
NPC1	inhibits	gene	0.60
T Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55

Incoming (20)

Source	Relation	Type	Str
AMPK	activates	protein	0.95
40395520	mediates	paper	0.90
LRRK2	phosphorylates	protein	0.90
C9Orf72-Smcr8	interacts_with	protein	0.90
C9orf72-SMCR8 Complex	modulates	protein	0.80
LRRK2	regulates	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
SMCR8	inhibits	gene	0.60
C9ORF72	inhibits	gene	0.60
LRRK2	activates	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
DEMENTIA	inhibits	gene	0.60
ALS	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
RAB7A	therapeutic_target	gene	0.60
IGF2R	therapeutic_target	gene	0.60
CAPZB	therapeutic_target	gene	0.60
RAB5A	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB8A in their description or question text

No additional research found