gene 614 words KG: RAB8A
Contents

RAB8A — RAB8A, Member RAS Oncogene Family

🧬 Gene Info
Gene SymbolRAB8A
Full NameRAB8A, Member RAS Oncogene Family
AliasesRas-Related Protein
Chromosome19p13.2
FunctionRAB8A encodes a member of the Rab GTPase family, which are key regulators of intracellular vesicle trafficking
Molecular Weight24 kDa
PathwaysCholesterol
UniProt IDP61006
NCBI Gene ID51528
Ensembl IDENSG00000135569
OMIM608030
GeneCardsRAB8A
Human Protein AtlasRAB8A
Associated Diseasesneurodegeneration
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, App, C9ORF72, C9Orf72-Smcr8
KG Connections60 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Lysosomal Enzyme Trafficking Correction
Score: 0.71
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: inhibits
Frontal and Temporal Lobe Selective Vulnerability in FT
experiment · KG edge: inhibits
ATG7 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

LRRK2 regulates RAB8A
RAB8A inhibits NPC1
RAB7A therapeutic_target RAB8A
IGF2R therapeutic_target RAB8A
CAPZB therapeutic_target RAB8A
RAB5A therapeutic_target RAB8A
HSPA1A therapeutic_target RAB8A
RAB8A therapeutic_target CANX
RAB8A therapeutic_target HSPA5
RAB8A regulates RAB11A

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