gene 2,944 words KG: ROCK2
Contents

ROCK2 Gene

🧬 Gene Info
Gene SymbolROCK2
Full NameRho-associated Protein Kinase 2
Chromosome2p24.1
Protein TypeSerine/Threonine Kinase
Functionencodes a serine/threonine kinase that functions as a major effector of the small GTPase RhoA.
Primary ExpressionUbiquitous, highest in testis
Subcellular LocalizationCytoplasmic, membrane
Molecular Weight160 kDa
Amino Acids388 aa
Exons33
PathwaysGlycolysis
GeneCardsROCK2
Human Protein AtlasROCK2
Associated DiseasesHuntington, neurodegeneration
InteractionsAKT, AND, APOPTOSIS, BRAIN INJURY, CALB2, CANCER
KG Connections88 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.85
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

Neurodegeneration
disease · KG edge: activates
Exosomes
entity · KG edge: activates
CALB2 Gene
gene · KG edge: activates
DNAJC5 Gene
gene · KG edge: activates
DNAJC6 — DnaJ Heat Shock Protein Family Member A6
gene · KG edge: regulates

Knowledge Graph (12 edges)

ROCK2 regulates HK2
ROCK1 activates ROCK2
ROCK2 activates PTEN
ROCK2 activates MTOR
ROCK2 activates AKT
GNA13 activates ROCK2
TAU biomarker_for ROCK2
GJA1 activates ROCK2
CALB2 activates ROCK2
DNAJC6 regulates ROCK2

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)