Contents

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

🧬 Gene Info

Gene Symbol	PIEZO1
Full Name	Piezo Type Mechanosensitive Ion Channel Component 1
Chromosome	16q24.3
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Small molecule modulator of mechanosensitive ion channel activity
Mechanism of Action	Small molecule modulator of mechanosensitive ion channel activity
Primary Expression	microglia, astrocytes, and brain endothelial cells, where it transduces mechanical cues from the ti
Druggability	Low (0.42)
Clinical Stage	Phase I
Molecular Weight	286 kDa
Amino Acids	521 aa
Exons	51
Pathways	Angiogenesis, Apoptosis, Autophagy, Calcium Signaling, Epigenetic
UniProt ID	Q9H5I5
NCBI Gene ID	9780
Ensembl ID	ENSG00000103335
OMIM	611184
GeneCards	PIEZO1
Human Protein Atlas	PIEZO1
Associated Diseases	Als, Alzheimer, Atherosclerosis, Bacterial Infection, calcium influx
Known Drugs/Compounds	artemisinin, Paeoniflorin, Yoda1
Interactions	Actin, ADAMTS5, AGING, AKT, ALS, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Extracellular Matrix Stiffness Modulation
KG Connections	927 knowledge graph edges
Databases	GeneCards HPA STRING

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Knowledge Graph

PIEZO1 interacts_with KCNK2

KCNK2 interacts_with PIEZO1

BMAL1 co_discussed PIEZO1

HK2 co_discussed PIEZO1

MIRO1 co_discussed PIEZO1

P2RY1 co_discussed PIEZO1

SOAT1 co_discussed PIEZO1

TET2 co_discussed PIEZO1

PIEZO1 co_discussed P2RX7

PIEZO1 co_discussed DGAT1