concept

PUTAMEN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PUTAMEN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

13Outgoing

45Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PUTAMEN
Key Genes/Proteins	ALPHA-SYNUCLEIN, C9orf72, CYP46A1, GBA
Related Diseases	ALZHEIMER'S DISEASE, COGNITIVE DECLINE, DEMENTIA, DOPAMINE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

putamen

brain_region · 2802 words

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Pathway Diagram

graph TD
    PUTAMEN["PUTAMEN"]
    TAU["TAU"] -->|"expressed in"| PUTAMEN
    PARKINSON["PARKINSON"] -->|"expressed in"| PUTAMEN
    HUNTINGTIN["HUNTINGTIN"] -->|"expressed in"| PUTAMEN
    CYP46A1["CYP46A1"] -->|"expressed in"| PUTAMEN
    HTT["HTT"] -->|"expressed in"| PUTAMEN
    HUNTINGTON["HUNTINGTON"] -->|"expressed in"| PUTAMEN
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| PUTAMEN
    SYNAPSE["SYNAPSE"] -->|"expressed in"| PUTAMEN

Outgoing (13)

Target	Relation	Type	Str
COGNITIVE DECLINE	interacts_with	phenotype	0.65
DOPAMINE	implicated_in	phenotype	0.55
FDG-PET	associated_with	biomarker	0.50
TH	associated_with	gene	0.50
NEURON	associated_with	cell_type	0.45
TYROBP	associated_with	gene	0.45
SORL1	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
JAK2	associated_with	gene	0.45
GBA	associated_with	gene	0.45
THALAMUS	co_discussed	brain_region	0.40
WHITE MATTER	co_discussed	brain_region	0.40
SUBSTANTIA NIGRA	co_discussed	brain_region	0.40

Incoming (45)

Source	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.80
C9orf72	interacts_with	gene	0.65
ASTROCYTES	treats	cell_type	0.65
ASTROCYTE	activates	cell_type	0.65
TYROBP	activates	gene	0.65
SORL1	activates	gene	0.65
AMYLOID	expressed_in	gene	0.55
Als	associated_with	disease	0.55
TAU	expressed_in	gene	0.55
BDNF	expressed_in	gene	0.55
HUNTINGTON	expressed_in	gene	0.55
ASTROCYTES	expressed_in	gene	0.55
SYNAPSE	expressed_in	gene	0.55
ASTROCYTE	expressed_in	gene	0.55
Huntington	associated_with	disease	0.55
HUNTINGTIN	expressed_in	gene	0.55
CYP46A1	expressed_in	gene	0.55
HTT	expressed_in	gene	0.55
Parkinson	associated_with	disease	0.55
Neurodegeneration	associated_with	disease	0.55
PARKINSON	expressed_in	gene	0.55
FUS	expressed_in	gene	0.55
TDP-43	expressed_in	gene	0.55
UBIQUITIN	expressed_in	gene	0.55
Neuron	expressed_in	cell_type	0.50
Dopaminergic	expressed_in	cell_type	0.50
ASTROCYTE	associated_with	cell_type	0.45
CYP46A1	associated_with	gene	0.45
DOPAMINERGIC NEURONS	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
ALPHA-SYNUCLEIN	associated_with	protein	0.45
ASTROCYTES	associated_with	cell_type	0.45
DOPAMINE	associated_with	phenotype	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
HUNTINGTON'S DISEASE	associated_with	disease	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
DEMENTIA	associated_with	disease	0.45
C9orf72	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
NEURONS	co_discussed	cell_type	0.40
NEURON	co_discussed	cell_type	0.40
DOPAMINERGIC	co_discussed	cell_type	0.40
BRAINSTEM	co_discussed	brain_region	0.40
CAUDATE	co_discussed	brain_region	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PUTAMEN in their description or question text

No additional research found