gene

PITX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PITX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

1Analyses

25Outgoing

37Incoming

0Experiments

1Debates

Summary

Page for PITX3 Gene

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🧬 Gene Info

Gene Symbol	PITX3
Full Name	Pituitary Homeobox 3
Chromosome	10q24.31
Protein Type	Transcription Factor
Target Class	Signaling Protein
Function	encodes a homeobox transcription factor critical for the development and survival of dopaminergic neurons.
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Primary Expression	diencephalic dopaminergic clusters
Druggability	Undruggable (0.20)
Molecular Weight	43 kDa
Amino Acids	394 aa
Pathways	insulin signaling
UniProt ID	O96038
NCBI Gene ID	5304
Ensembl ID	ENSG00000107807
OMIM	602618
GeneCards	PITX3
Human Protein Atlas	PITX3
Associated Diseases	als, ms, neurodegeneration, parkinson, Parkinson's disease
Known Drugs/Compounds	levodopa
Interactions	BCL2, DAT, EN1, EN2, FOXA2, LMX1A
SciDEX Target	View Target Profile
KG Connections	62 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PITX3 — AlphaFold O96038 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PITX3 Gene

gene · 899 words

→

PITX3 Protein

protein · 2967 words

→

Pathway Diagram

graph TD
    PITX3["PITX3"]
    Parkinson{"Parkinson"}
    PITX3 -->|"expressed in"| Parkinson
    BCL2["BCL2"]
    PITX3 -->|"activates"| BCL2
    Apoptosis(["Apoptosis"])
    PITX3 -->|"expressed in"| Apoptosis
    neurodegeneration["neurodegeneration"]
    PITX3 -->|"implicated in"| neurodegeneration
    NOXA["NOXA"]
    NOXA -->|"activates"| PITX3
    BAX["BAX"]
    BAX -->|"expressed in"| PITX3
    style PITX3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Parkinson	expressed_in	disease	0.65
BCL2	activates	gene	0.60
Apoptosis	expressed_in	pathway	0.60
TH	activates	gene	0.55
insulin signaling	participates_in	pathway	0.55
neurons	expressed_in	cell_type	0.55
RNA	interacts_with	gene	0.55
dopaminergic neurons	expressed_in	cell_type	0.55
RNA	associated_with	gene	0.55
Parkinson's disease	associated_with	disease	0.55
stem cells	expressed_in	cell_type	0.55
RNA	debate_co_mention	gene	0.45
SIRT1	debate_co_mention	gene	0.45
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
synaptic plasticity genes	co_discussed	gene	0.40
HMGCR	co_discussed	gene	0.40
mitochondrial biogenesis genes	co_discussed	gene	0.40
DMPK	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
neurodegeneration	associated_with	disease	0.37
neuronal identity transcription factors	interacts_with	gene	0.37
NURR1	interacts_with	gene	0.37
ms	implicated_in	disease	0.35
parkinson	implicated_in	disease	0.35
als	implicated_in	disease	0.35

Incoming (37)

Source	Relation	Type	Str
h-9d22b570	targets_gene	hypothesis	0.90
BAX	expressed_in	gene	0.60
NOXA	activates	gene	0.60
DAT	activates	gene	0.55
NR4A2	regulates	gene	0.55
NURR1	regulates	gene	0.55
NURR1	associated_with	gene	0.55
NURR1	activates	gene	0.55
levodopa	targets	drug	0.55
EN1	activates	gene	0.55
EN2	activates	gene	0.55
FOXA2	activates	gene	0.55
LMX1A	activates	gene	0.55
LDLR	debate_co_mention	gene	0.45
Cell-type-specific essential genes	debate_co_mention	gene	0.45
BDNF	debate_co_mention	gene	0.45
FOXO3	debate_co_mention	gene	0.45
APOE	co_discussed	gene	0.40
repeat-containing transcripts	co_discussed	gene	0.40
neuronal identity transcription factors	co_discussed	gene	0.40
DMPK	co_discussed	gene	0.40
Cell-type-specific essential genes	co_discussed	gene	0.40
synaptic plasticity genes	co_discussed	gene	0.40
HMGCR	co_discussed	gene	0.40
mitochondrial biogenesis genes	co_discussed	gene	0.40
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
PGC1A	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
NURR1	interacts_with	gene	0.37
neuronal identity transcription factors	interacts_with	gene	0.37

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03