| Gene Symbol | ent-gene-69e4f0e3 |
| Function | Rapid calcium influx upon ATP activation, leading to downstream signaling cascades |
| Structure | Trimeric assembly forming a non-selective cation channel |
| Location | High expression on microglia, macrophages, and peripheral immune cells; lower expression on neurons and astrocytes |
| N-terminal extracellular domain | ATP binding site (~280 residues) |
| Two transmembrane domains | Form the channel pore |
| C-terminal intracellular tail | Extended cytoplasmic domain (~220 residues) critical for signaling |
| ATP-binding pocket | Hydrophobic cavity for nucleotide recognition |
| Zinc binding site | Allosteric modulation |
| C-terminal proline-rich region | Protein interaction domain |
| NLRP3 inflammasome | ASC speck formation, caspase-1 activation |
| NF-κB pathway | TNF-α and IL-6 transcription |
| MAPK activation | p38, JNK, ERK phosphorylation |
| PI3K/Akt signaling | Cell survival modulation |
| ROS generation | NADPH oxidase activation |
| Extracellular ATP increases | From damaged dopaminergic neurons, synaptic leakage |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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