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gene 1,181 words KG: P2X7
Contents

Purinergic Receptor P2X 7 (P2X7)

🧬 Gene Info
Gene SymbolP2X7
Full NameP2X Purinoceptor 7
Chromosome12q24.31.
Protein TypeChannel
FunctionIn the healthy brain, P2X7 serves several important physiological roles:
Molecular Weight68.5 kDa
Amino Acids595 aa
Exons17
PathwaysAmyloid, Apoptosis, Er Stress, Inflammasome, Microrna
Ensembl IDENSG00000088038
GeneCardsP2X7
Human Protein AtlasP2X7
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Autoimmune, Cancer
Interactionsadnp, ADNP, AKT, ALS, ALZHEIMER, AMYLOID
KG Connections370 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (14)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78APOE-TREM2 Interaction Modulation
Score: 0.74Aquaporin-4 Polarization Rescue
Score: 0.73Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72Purinergic Signaling Polarization Control
Score: 0.71Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Microglial Purinergic Reprogramming
Score: 0.70Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56Temporal Decoupling via Circadian Clock Reset
Score: 0.54Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36

Related Analyses (10)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (5)

P2rx7 congenic mouse model insulin tolerance testing
validation · proposed · Score: 0.90P2rx7 congenic mouse model glucose tolerance testing
validation · proposed · Score: 0.90ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40

See Also (13)

ATP P2X3 Receptor Neurons
cell · KG edge: activatesAmyotrophic Lateral Sclerosis
redirect · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesAstrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

P2RY1 associated_with P2X7
P2X7 associated_with P2RX7
P2X7 associated_with P2RX4
P2RX7 activates P2X7
NLRP3 expressed_in P2X7
P2X7 activates P2RX7
P2X7 activates P2RX4
PANX1 activates P2X7
P2X7 activates SRC
P2RX4 associated_with P2X7

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