Contents

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration

🔬 Protein Info

Gene Symbol	ent-gene-69e4f0e3
Protein Family	Pannexin gap junction proteins (PANX1, PANX2, PANX3) - evolutionary distinct from connexins
Structure	Heptameric hemichannel (seven subunits) forming a large-pore channel
Conductance	~500 pS when fully opened, allowing passage of molecules up to 1 kDa
Regulation	Multiple mechanisms control channel activity including caspase-3/7 cleavage, voltage-gated activation, intracellular Ca2+ changes, and mechanical stress
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

No AI portrait yet

Knowledge Graph