protein 1,675 words KG: P2X7
Contents

P2X7 — P2X Purinoceptor 7

🔬 Protein Info
Gene SymbolP2X7
Full NameP2X Purinoceptor 7
Chromosome12q24.31.
Protein TypeChannel
FunctionIn the healthy brain, P2X7 serves several important physiological roles:
Molecular Weight68.5 kDa
Amino Acids595 aa
Exons17
PathwaysAmyloid, Apoptosis, Er Stress, Inflammasome, Microrna
Ensembl IDENSG00000088038
GeneCardsP2X7
Human Protein AtlasP2X7
Associated DiseasesAls, Alzheimer, Alzheimer'S Disease, Autoimmune, Cancer
Interactionsadnp, ADNP, AKT, ALS, ALZHEIMER, AMYLOID
KG Connections375 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (14)

APOE-TREM2 Interaction Modulation
Score: 0.74
Purinergic Signaling Polarization Control
Score: 0.71
Microglial Purinergic Reprogramming
Score: 0.70
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78

Related Analyses (7)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

P2rx7 congenic mouse model insulin tolerance testing
validation · proposed · Score: 0.90
P2rx7 congenic mouse model glucose tolerance testing
validation · proposed · Score: 0.90
Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40

See Also (12)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Astrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

P2RY1 associated_with P2X7
P2X7 associated_with P2RX7
P2X7 associated_with P2RX4
P2RX7 activates P2X7
NLRP3 expressed_in P2X7
P2X7 activates P2RX7
P2X7 activates P2RX4
PANX1 activates P2X7
P2X7 activates SRC
P2RX4 associated_with P2X7

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