gene 861 words KG: NEIL1
Contents

NEIL1 — Nei Endonuclease VIII-Like 1

🧬 Gene Info
Gene SymbolNEIL1
Full NameNei Endonuclease VIII-Like 1
Chromosome15q24.2
FunctionThe NEIL1 gene encodes a 406-amino acid DNA glycosylase that initiates base excision repair by recognizing and removing damaged bases:
Amino Acids406 aa
UniProt IDQ9Y3X0
NCBI Gene ID57478
Ensembl IDENSG00000140323
OMIM608747
GeneCardsNEIL1
Human Protein AtlasNEIL1
Associated Diseasesneurodegeneration
InteractionsABCB1, APOPTOSIS, ATM, BRAF, CANCER, COMPLEMENT
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (3)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
VCP-Mediated Autophagy Enhancement
Score: 0.59
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (3)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · completed · Score: 0.40

See Also (14)

Apoptosis in Neurodegeneration
entity · KG edge: inhibits
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: interacts_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: activates
ATM Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TREX1 interacts_with NEIL1
VCP interacts_with NEIL1
NEIL1 interacts_with POLD1
NEIL1 interacts_with POT1
NEIL1 interacts_with MRE11
NEIL1 interacts_with MUTYH
NEIL1 interacts_with SAMHD1
NEIL1 interacts_with NBS1
NEIL1 interacts_with LMNA
NEIL1 interacts_with WRN

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