| Gene Symbol | NEIL1 |
| Full Name | Nei Endonuclease VIII-Like 1 |
| Chromosome | 15q24.2 |
| Function | The NEIL1 gene encodes a 406-amino acid DNA glycosylase that initiates base excision repair by recognizing and removing damaged bases: |
| Amino Acids | 406 aa |
| UniProt ID | Q9Y3X0 |
| NCBI Gene ID | 57478 |
| Ensembl ID | ENSG00000140323 |
| OMIM | 608747 |
| GeneCards | NEIL1 |
| Human Protein Atlas | NEIL1 |
| Helix-hairpin-helix (HhH) motif | Common DNA binding structure in glycosylases |
| Catalytic Residue | Asp⁷⁵ acts as the nucleophile that cleaves the glycosidic bond |
| Base Flipping Mechanism | The enzyme extrudes damaged bases from the DNA helix for inspection |
| Zinc Finger | Stabilizes DNA binding and lesion recognition |
| Associated Diseases | neurodegeneration |
| Interactions | ABCB1, APOPTOSIS, ATM, BRAF, CANCER, COMPLEMENT |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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