gene

IL20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

7Outgoing

2Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	IL20
Full Name	Interleukin 20
Chromosome	1q32.1
Protein Family	IL-20 cytokine subfamily
Function	is a class I cytokine with a characteristic four-helix bundle structure common to the IL-10 family.
Primary Expression	MS lesions and may contribute to demyelination and disease progression[@chen2018]:
Molecular Weight	20 kDa
Amino Acids	176 aa
Exons	5
UniProt ID	Q9NZX1
NCBI Gene ID	50603
Ensembl ID	ENSG00000158315
OMIM	605619
GeneCards	IL20
Human Protein Atlas	IL20
Associated Diseases	neurodegeneration
Interactions	CXCL8, Il-1, IL-1, IL6, STAT3, TNF
KG Connections	9 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL20 — AlphaFold Q9NZX1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL20 (Interleukin 20)

gene · 2384 words

→

Pathway Diagram

flowchart TD
    N0["IL20"]
    N1["CXCL8"]
    N0 -->|"activates"| N1
    N2["STAT3"]
    N0 -->|"activates"| N2
    N3["IL6"]
    N0 -->|"activates"| N3
    N4["T Cell"]
    N0 -->|"activates"| N4
    N5["Mast Cell"]
    N0 -->|"activates"| N5
    N6["Neutrophil"]
    N0 -->|"activates"| N6
    N7["Il-1"]
    N0 -->|"activates"| N7
    N8["TNF"]
    N8 -->|"activates"| N0
    N9["IL-1"]
    N9 -->|"activates"| N0
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene
    class N7 protein
    class N8 gene
    class N9 gene

Outgoing (7)

Target	Relation	Type	Str
CXCL8	activates	gene	0.60
STAT3	activates	gene	0.60
IL6	activates	gene	0.60
Mast Cell	activates	cell_type	0.60
T Cell	activates	cell_type	0.60
Neutrophil	activates	cell_type	0.60
Il-1	activates	protein	0.60

Incoming (2)

Source	Relation	Type	Str
TNF	activates	gene	0.60
IL-1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL20 in their description or question text

No additional research found