| Gene Symbol | YKL |
| Full Name | 40 (Chitinase-3-like protein 1) |
| Chromosome | 1q32.1 |
| Function | YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is a secreted glycoprotein belonging to the glycoside hydrolase family 18[@chitinase2020]. |
| GeneCards | YKL |
| Human Protein Atlas | YKL |
| Chitin-binding domain | Enables interaction with extracellular matrix components |
| Heparin-binding region | Interacts with proteoglycans and cell surfaces |
| TGF-beta | Moderate induction |
| IFN-gamma | Synergizes with IL-6 |
| Lipopolysaccharide (LPS) | Strong induction via TLR4 |
| Amyloid-beta | Direct activation of microglial YKL-40 production |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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