| Gene Symbol | YKL |
| Full Name | 40 Protein |
| Aliases | YKL40PROTEIN |
| Chromosome | 1q32.1 |
| Function | YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is a secreted glycoprotein belonging to the glycoside hydrolase family 18[@chitinase2020]. |
| GeneCards | YKL |
| Human Protein Atlas | YKL |
| Inflammatory cytokines | IL-6, IL-1β, and TNF-α upregulate expression |
| Growth factors | TGF-β and PDGF modulate CHI3L1 levels |
| Cellular stress | Hypoxia and oxidative stress induce expression |
| Tissue-specific factors | Different cell types show distinct regulation patterns[@chil2020] |
| Signal peptide | 20 amino acid N-terminal signal sequence for secretion |
| Chitinase-like domain | The defining feature with the conserved GH18 fold |
| Theonine-rich region | O-glycosylated region |
| Hinge region | Flexible linker between domains |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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