gene 736 words KG: ent-gene-02875fe0
Contents

CDKL5

🧬 Gene Info
Gene SymbolCDKL5
Full NameCyclin-Dependent Kinase-Like 5
ChromosomeXp22.13
Protein FamilyCDK family (CDK1-18), MAPK/CDK group
Protein TypeKinase
Functionencodes a serine-threonine kinase expressed predominantly in the developing brain, particularly in neurons.
Primary ExpressionBrain (neurons, high in cortex, hippocampus, cerebellum); low elsewhere
Molecular Weight145 kDa
Amino Acids075 aa
PathwaysMAPK
UniProt IDQ6VAC4
NCBI Gene ID6792
Ensembl IDENSG00000008086
OMIM300203
GeneCardsCDKL5
Human Protein AtlasCDKL5
Associated Diseasesneurodegeneration
InteractionsAPOPTOSIS, ERK
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (1)

HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65

Related Analyses (12)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Mitochondrial transfer between neurons and glia
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (5)

Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (6)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: activates
Neurogenesis
entity · KG edge: activates
Genes
index · KG edge: contributes_to
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (4 edges)

h-42d01f0454 targets ent-gene-02875fe0
ent-gene-02875fe0 targeted_by h-42d01f0454
ent-gene-02875fe0 data_in benchmark_ot_ad_answer_key:CDKL5
benchmark_ot_ad_answer_key:CDKL5 data_in ent-gene-02875fe0

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