concept

EXTRACELLULAR MATRIX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXTRACELLULAR MATRIX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections

1Hypotheses

1Analyses

29Outgoing

50Incoming

3Experiments

1Debates

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💡 Concept Info

Name	EXTRACELLULAR MATRIX
Key Genes/Proteins	adamts4, ALZHEIMER, APOE, BMAL1, CD44
Related Diseases	aging, Alzheimer'S Disease, cancer

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Extracellular Matrix and Integrin Modulator Therapy for Neurodegeneration

therapeutic · 1681 words

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Pathway Diagram

graph TD
    EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"]
    EXTRACELLULAR_MATRIX -->|"regulates"| Vascular_Homeostasis["Vascular Homeostasis"]
    EXTRACELLULAR_MATRIX -->|"component_of"| Neurovascular_Unit["Neurovascular Unit"]
    EXTRACELLULAR_MATRIX -->|"contributes to"| Vascular_Disease["Vascular Disease"]
    EXTRACELLULAR_MATRIX -->|"regulates"| Vessel_Remodelling["Vessel Remodelling"]
    EXTRACELLULAR_MATRIX -->|"involved_in"| Vascular_Development["Vascular Development"]
    EXTRACELLULAR_MATRIX -->|"involved_in"| Radioresistance["Radioresistance"]
    EXTRACELLULAR_MATRIX -->|"modulates"| Disease_Initiation["Disease Initiation"]
    PERLECAN["PERLECAN"] -->|"component_of"| EXTRACELLULAR_MATRIX
    LOXL3["LOXL3"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    LOX_FAMILY["LOX FAMILY"] -->|"regulates"| EXTRACELLULAR_MATRIX
    ECM_Producing_Cells["ECM-Producing Cells"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    LOX["LOX"] -->|"involved_in"| EXTRACELLULAR_MATRIX
    Lysyl_Oxidase["Lysyl Oxidase"] -->|"modulates"| EXTRACELLULAR_MATRIX
    JUN["JUN"] -->|"inhibits"| EXTRACELLULAR_MATRIX
    HAPLN4["HAPLN4"] -->|"participates in"| EXTRACELLULAR_MATRIX

Outgoing (29)

Target	Relation	Type	Str
Vascular Homeostasis	regulates	process	0.95
Vascular Disease	associated_with	disease	0.95
Vessel Remodelling	regulates	process	0.90
Neurovascular Unit	component_of	process	0.90
Cancer Cell Proliferation	associated_with	phenotype	0.90
Disease Initiation	contributes_to	process	0.88
Disease Progression	contributes_to	process	0.88
Vascular Development	involved_in	process	0.88
fibrosis	contributes_to	phenotype	0.88
Chronic Kidney Disease	involved_in	disease	0.85
Radioresistance	involved_in	phenotype	0.85
Colorectal Cancer	involved_in	disease	0.85
Vascular Ageing	involved_in	phenotype	0.85
Angiogenesis	associated_with	process	0.85
Radioresistance	contributes_to	phenotype	0.85
Disease Initiation	modulates	process	0.85
Disease Progression	modulates	process	0.85
ALS	involved_in	disease	0.80
Vascular Ageing	contributes_to	phenotype	0.80
Prostate Cancer	regulates	disease	0.80
Immune Evasion	associated_with	phenotype	0.80
Neurite Outgrowth	regulates	process	0.70
synaptic remodeling	regulates	process	0.70
C1q deposition	regulates	process	0.70
C3 deposition	regulates	process	0.70
WNT SIGNALING	associated_with	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
CELL MIGRATION	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50

Incoming (106)

Source	Relation	Type	Str
Microglia	degrades	cell_type	0.95
PERLECAN	component_of	protein	0.95
LOXL3	involved_in	gene	0.95
Lysyl Oxidase	modulates	enzyme	0.90
LOX FAMILY	regulates	gene	0.90
ECM-Producing Cells	involved_in	cell_type	0.90
HSPG2	involved_in	protein	0.90
Integrin	interacts_with	receptor	0.88
Environmental Cues	modulates	process	0.85
Car-T Cell	inhibits	cell_type	0.85
Integrins	interacts_with	receptor	0.85
programmed cell death	associated_with	process	0.80
JUN	inhibits	protein	0.80
HAPLN4	participates_in	gene	0.80
Cell-Matrix Interactions	interacts_with	process	0.80
MMP9	remodels	gene	0.80
HAPLN4	participates_in	gene	0.70
OSR2	regulates	gene	0.70
SNCA triplication	modulates	gene	0.70
cancer	activates	disease	0.50
HIPPO	activates	concept	0.50
cancer	associated_with	disease	0.50
TUMOR	activates	disease	0.50
Invasion	activates	pathway	0.50
TUBB3	activates	gene	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
adamts4	activates	gene	0.50
BMAL1	activates	protein	0.50
ENDOTHELIAL	activates	concept	0.50
GPX4	inhibits	gene	0.50
ferroptosis	inhibits	phenotype	0.50
FIBROSIS	activates	disease	0.50
disease	activates	disease	0.50
Pulmonary Fibrosis	activates	disease	0.50
inflammation	activates	pathway	0.50
Synaptic Plasticity	associated_with	pathway	0.50
Astrocyte	inhibits	cell_type	0.50
MYELIN	inhibits	concept	0.50
Proteostasis	interacts_with	process	0.50
Proteins	interacts_with	protein	0.50
inflammation	associated_with	pathway	0.50
CELL PROLIFERATION	associated_with	concept	0.50
NEURONS	expressed_in	concept	0.50
inflammation	interacts_with	pathway	0.50
aging	interacts_with	phenotype	0.50
Fibroblast	interacts_with	cell_type	0.50
Reactive Oxygen Species	interacts_with	process	0.50
FIBROBLASTS	interacts_with	concept	0.50
MACROPHAGES	interacts_with	concept	0.50
OVERVIEW	associated_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Extracellular Matrix Stiffness Modulation	0.691	neurodegeneration	Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Microglial activation by bEVs via Piezo1	exploratory	Alzheimer's disease	0.900	0.00	microglia (in vivo and in vitr	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$240,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$200,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720]	Harraz OF, Hashad AM	Physiology (Bethesda)	2026	1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160]	Wang Y, Wang J, Zhang J, Wang Y, Wang Y,	Sci Adv	2024	1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007]	Zong B, Yu F, Zhang X, Pang Y, Zhao W, S	Ageing Res Rev	2023	1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296]	Jiang Y, Zhang H, Wang J, Liu Y, Luo T,	J Hematol Oncol	2022	1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671]	Atcha H, Jairaman A, Holt JR, Meli VS, N	Nat Commun	2021	1
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT [PMID:41175920]	Sun H, Wu Z, Zhang Y, Liu C, Gao D et al	Osteoarthritis Cartilage	2026	0
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolis [PMID:41486513]	Ma J, Xie N, Wang Z, Liang X, Han Y et a	Adv Sci (Weinh)	2026	0
Insights into the role of the mechanosensitive Piezo1 channel and signaling mech [PMID:41544798]	Zhang M, Ge Y, Wang Z, Li H, Wang G et a	Neurosci Biobehav Rev	2026	0
Long-range chemical signalling in vivo is regulated by mechanical signals. [PMID:41555045]	Pillai EK, Mukherjee S, Gampl N, McGinn	Nat Mater	2026	0
The Glymphatic System and Meningeal Lymphatics: Current Understandings and Futur [PMID:41930354]	Sun H, Fan H, Zhou Y, Zhu H, Chen Y et a	MedComm (2020)	2026	0
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265]	["Li R", "Xia J", "Shi C", "Zhang K", "Q	Journal of advanced research	2026	0
Piezo1 is a pathogenic gene and therapeutic target for neurological diseases. [PMID:40276938]	Wang H, Gou Z, Chen S, Lu L	The International journal of n	2026	0
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420]	Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li	Frontiers in molecular bioscie	2025	0
PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683]	Gupta T, Singh TG, Singh R	Molecular biology reports	2025	0
Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion [PMID:38744281]	Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi	Cell	2024	0
The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing nov [PMID:35236990]	["Costello S", "Shoemaker S", "Hobbs H",	Nature structural & molecular	2022	0
Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hep [PMID:36181398]	Li M, Zhang X, Wang M, Wang Y, Qian J, X	Cancer communications (London,	2022	0
A process-based approach to understanding and managing triggered seismicity. [PMID:34321668]	["Hager B", "Dieterich J", "Frohlich C",	Nature	2021	0
Searching for female reproductive aging and longevity biomarkers. [PMID:34156973]	["Yureneva S", "Averkova V", "Silachev D	Aging	2021	0
ANCA associated vasculitis. [PMID:32291255]	Robert W Hunter; Nicola Welsh; Tariq E F	BMJ (Clinical research ed.)	2020	0

Debates (1)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning EXTRACELLULAR MATRIX in their description or question text

No additional research found