Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALZHEIMER_DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ALZHEIMER_DISEASE |
| Key Genes/Proteins | CYP46A1, EPILEPSY, GFAP |
| Related Diseases | ER_STRESS, INFLAMMATION, INSULIN_RESISTANCE, TYPE2_DIABETES |
| Related Pathways | COMPLEMENT |
graph TD
ALZHEIMER_DISEASE["ALZHEIMER_DISEASE"]
GADD45G["GADD45G"] -->|"activates"| ALZHEIMER_DISEASE
CYP46A1["CYP46A1"] -->|"target for"| ALZHEIMER_DISEASE
INFLAMMATION["INFLAMMATION"] -->|"contributes to"| ALZHEIMER_DISEASE
ER_STRESS["ER_STRESS"] -->|"contributes to"| ALZHEIMER_DISEASE
PHYTOCHEMICALS["PHYTOCHEMICALS"] -->|"treats"| ALZHEIMER_DISEASE
APOE["APOE"] ---|"associated"| ALZHEIMER_DISEASE
COMPLEMENT["COMPLEMENT"] ---|"associated"| ALZHEIMER_DISEASE
TYROBP["TYROBP"] ---|"associated"| ALZHEIMER_DISEASE
C1QC["C1QC"] ---|"associated"| ALZHEIMER_DISEASE
CO9["CO9"] ---|"associated"| ALZHEIMER_DISEASE| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| tau_propagation | contributes_to | pathway | 0.00 |
| spatial_navigation | risk_factor_for | cognitive_function | 0.90 |
| EPILEPSY | associated_with | gene | 0.80 |
| INSULIN_RESISTANCE | implicated_in | phenotype | 0.80 |
| antibody_transcytosis | treats | pathway | 0.80 |
| APOE | associated_with | gene | 0.72 |
| neuroinflammation | causes | mechanism | 0.70 |
| EPILEPSY | interacts_with | gene | 0.70 |
| CASP3 | associated_with | gene | 0.70 |
| TYROBP | associated_with | protein | 0.64 |
| C1QC | associated_with | protein | 0.64 |
| CO9 | associated_with | protein | 0.64 |
| TYPE2_DIABETES | associated_with | disease | 0.64 |
| RSU1 | associated_with | protein | 0.64 |
| ADA10 | associated_with | protein | 0.64 |
| GFAP | associated_with | protein | 0.64 |
| GP1BB | associated_with | protein | 0.64 |
| COMPLEMENT | associated_with | pathway | 0.64 |
| GADD45G | activates | gene | 0.64 |
| CYP46A1 | therapeutic_target | gene | 0.60 |
| exosomes | associated_with | phenotype | 0.56 |
| caspase_6 | associated_with | protein | 0.56 |
| INFLAMMATION | contributes_to | phenotype | 0.56 |
| ER_STRESS | contributes_to | phenotype | 0.56 |
| lipid_metabolism | dysregulated_in | pathway | 0.50 |
| PHYTOCHEMICALS | treats | drug | 0.50 |
| oligodendrocyte_dysfunction | contributes_to | pathological_process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
memory and navigation | 2026-04-08 | 0 hypotheses
clinical neurology | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-04 | 15 hypotheses Top: 0.814
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.726
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.90 · 2026-04-12
closed · Rounds: 4 · Score: 0.79 · 2026-04-09
closed · Rounds: 4 · Score: 0.95 · 2026-04-09
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning ALZHEIMER_DISEASE in their description or question text
No additional research found