gene 740 words KG: DNAJA1
Contents

DnaJ Heat Shock Protein Family (Hsp40) Member A1

🧬 Gene Info
Gene SymbolDNAJA1
Full NameDnaJ Heat Shock Protein Family (Hsp40) Member A1
Chromosome9p13.3
Protein FamilyDnaJ/Hsp40 family
Protein TypeChaperone
Functionis an important component in the neurobiology of neurodegenerative diseases.
UniProt ID[P31689](https://www.uniprot.org/uniprot/P31689)
NCBI Gene ID1652
Ensembl IDENSG00000116001
OMIM601067
GeneCardsDNAJA1
Human Protein AtlasDNAJA1
Client protein recognitionIdentifies misfolded proteins
Hsp70 recruitmentRecruits Hsp70 (HSPA1A) to substrates
ATP hydrolysis stimulationEnhances Hsp70 ATPase activity
Associated Diseasesneurodegeneration
InteractionsABCB1, ALZHEIMER, ALZHEIMER'S DISEASE, ATP1B1, ATP1B3, DNAJB1
KG Connections63 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

FUS (Redirect)
redirect · KG edge: inhibits
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: interacts_with
ATP1B1 Gene
gene · KG edge: interacts_with
atp1b3
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ENO1 biomarker_for DNAJA1
DNAJA1 activates HSPA1A
DNAJA1 biomarker_for FLT1
DNAJA1 biomarker_for HSPA8
DNAJA1 activates GPX4
IREB2 interacts_with DNAJA1
DNAJA1 interacts_with ATP1B1
DNAJA1 interacts_with ATP1B3
DNAJA1 interacts_with ABCB1
DNAJB6 inhibits DNAJA1

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