protein

ATAXIN-3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATAXIN-3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

7Outgoing

10Incoming

0Experiments

0Debates

Summary

Ataxin-3 (Josephin)

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🔬 Protein Info

Gene Symbol	ATAXIN
Protein Family	Josephin family (deubiquitinating enzymes)
Function	Ataxin-3 (ATXN3) is a deubiquitinating enzyme encoded by the ATXN3 gene
Subcellular Localization	Cytoplasm, Nucleus
UniProt ID	P54252
GeneCards	ATAXIN
Human Protein Atlas	ATAXIN
Interactions	dnaja1, DNAJB1, DNAJB2, DNAJB6, HUNTINGTON, Proteins
KG Connections	17 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — ATAXIN-3 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1YZB — X-ray / Cryo-EM

🔮 AI Predicted Structure

P54252 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

flowchart TD
    N0["ATAXIN-3"]
    N1["NEURONS"]
    N0 -->|"associated with"| N1
    N2["HCRT"]
    N0 -->|"associated with"| N2
    N3["HUNTINGTON"]
    N0 -->|"inhibits"| N3
    N4["Chaperone"]
    N0 -->|"inhibits"| N4
    N5["Proteins"]
    N0 -->|"inhibits"| N5
    N6["Cortex"]
    N0 -->|"regulates"| N6
    N7["FRONTAL"]
    N0 -->|"regulates"| N7
    N8["Genes"]
    N0 -->|"associated with"| N8
    N9["narcolepsy"]
    N9 -->|"associated with"| N0
    N10["dnaja1"]
    N10 -->|"inhibits"| N0
    N11["DNAJB2"]
    N11 -->|"inhibits"| N0
    N12["DNAJB1"]
    N12 -->|"inhibits"| N0
    N13["DNAJB6"]
    N13 -->|"inhibits"| N0
    N9 -->|"regulates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N3 gene
    class N4 pathway
    class N5 protein
    class N9 disease
    class N10 gene
    class N11 gene
    class N12 gene
    class N13 gene

Outgoing (7)

Target	Relation	Type	Str
HUNTINGTON	inhibits	gene	0.50
Chaperone	inhibits	pathway	0.50
Proteins	inhibits	protein	0.50
Cortex	regulates	brain_region	0.50
FRONTAL	regulates	concept	0.50
NEURONS	associated_with	concept	0.50
HCRT	associated_with	concept	0.50

Incoming (10)

Source	Relation	Type	Str
narcolepsy	associated_with	disease	0.50
HUNTINGTIN	associated_with	protein	0.50
ATXN3	associated_with	gene	0.50
dnaja1	inhibits	gene	0.50
DNAJB2	inhibits	gene	0.50
DNAJB1	inhibits	gene	0.50
DNAJB6	inhibits	gene	0.50
narcolepsy	regulates	disease	0.50
HCRTR2	regulates	gene	0.50
HCRTR1	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATAXIN-3 in their description or question text

No additional research found