gene

ATP1B1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP1B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

13Outgoing

6Incoming

0Experiments

0Debates

Summary

ATPase Na+/K+ transporting subunit beta 1 - neuronal ion pump component

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🧬 Gene Info

Gene Symbol	ATP1B1
Aliases	ATPase Na+/K+ transporting subunit beta 1
Function	is a protein encoded by the ATP1B1 gene.
Molecular Weight	35 kDa
Amino Acids	270 aa
Pathways	Autophagy, Drug Resistance, Chemoresistance, Multidrug Resistance
UniProt ID	P05026
GeneCards	ATP1B1
Human Protein Atlas	ATP1B1
Resting membrane potential	Maintains the -70mV resting potential
Action potential generation	Enables sodium influx for depolarization
Secondary transporter function	Powers neurotransmitter reuptake
Neuronal excitability	Regulates ion homeostasis
Calcium regulation	Indirectly controls calcium through sodium gradient
Associated Diseases	neurodegeneration
Interactions	ABCB1, ATP1B3, AUTOPHAGY, CANCER, DNAJA1, GENES
KG Connections	19 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATP1B1 — AlphaFold P05026 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATP1B1 Gene

gene · 1564 words

→

ATP1B1 Protein

protein · 524 words

→

Pathway Diagram

graph TD
    ATP1B1["ATP1B1"]
    ATP1B3["ATP1B3"]
    ATP1B1 -->|"interacts with"| ATP1B3
    ABCB1["ABCB1"]
    ATP1B1 -->|"interacts with"| ABCB1
    neurodegeneration["neurodegeneration"]
    ATP1B1 -->|"implicated in"| neurodegeneration
    IREB2["IREB2"]
    IREB2 -->|"interacts with"| ATP1B1
    DNAJA1["DNAJA1"]
    DNAJA1 -->|"interacts with"| ATP1B1
    style ATP1B1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	0.65
Breast Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Drug Resistance	activates	pathway	0.60
Chemoresistance	therapeutic_target	pathway	0.60
CANCER	activates	gene	0.60
Multidrug Resistance	activates	pathway	0.60
GENES	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
ATP1B3	interacts_with	gene	0.60
ABCB1	interacts_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
LYSOSOMAL BIOGENESIS	activates	gene	0.60
ROS	therapeutic_target	gene	0.60
LYSOSOME	activates	gene	0.60
IREB2	interacts_with	gene	0.60
DNAJA1	interacts_with	gene	0.60
TFEB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATP1B1 in their description or question text

No additional research found