concept

DNA REPAIR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNA REPAIR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

589Connections

2Hypotheses

1Analyses

43Outgoing

50Incoming

0Experiments

1Debates

Summary

DNA REPAIR is a concept in neurodegeneration research. Key relationships include: co discussed, contributes to, inhibits. Associated with HUNTINGTON, TUMOR. Connected to 13 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	DNA REPAIR
Key Genes/Proteins	ABCB1, ALOX12, ALOX5, BRCA1, CD38, CGAS
Related Diseases	BREAST CANCER, CANCER, COLORECTAL CANCER

Pathway Diagram

graph TD
    DNA_REPAIR["DNA REPAIR"]
    APE2["APE2"] -->|"participates in"| DNA_REPAIR
    CGAS["CGAS"] -->|"regulates"| DNA_REPAIR
    cGAS["cGAS"] -->|"regulates"| DNA_REPAIR
    IRF3["IRF3"] -->|"activates"| DNA_REPAIR
    MAX["MAX"] -->|"activates"| DNA_REPAIR
    PARP1["PARP1"] -->|"activates"| DNA_REPAIR
    STING["STING"] -->|"activates"| DNA_REPAIR
    CLOCK["CLOCK"] -->|"regulates"| DNA_REPAIR
    P53["P53"] -->|"inhibits"| DNA_REPAIR

Outgoing (43)

Target	Relation	Type	Str
Radiotherapy Resistance	contributes_to	phenotype	0.90
Neuronal Functions	protects_against	phenotype	0.85
Frontotemporal Dementia	associated_with	disease	0.85
Chromatin Organization	modulates	mechanism	0.80
Macrophage	activates	cell_type	0.50
Macrophage	biomarker_for	cell_type	0.50
T Cell	activates	cell_type	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
CELL DEATH	inhibits	concept	0.50
Proteins	interacts_with	protein	0.50
HUNTINGTON'S	associated_with	concept	0.50
T Cell	expressed_in	cell_type	0.50
Microglia	associated_with	cell_type	0.50
Neuron	causes	cell_type	0.50
Macrophage	causes	cell_type	0.50
Neuron	contributes_to	cell_type	0.50
T Cell	associated_with	cell_type	0.50
DNA DAMAGE	associated_with	concept	0.50
Ovarian Cancer	inhibits	disease	0.50
T Cell	therapeutic_target	cell_type	0.50
GENETIC MODIFIERS	interacts_with	concept	0.50
Neuron	therapeutic_target	cell_type	0.50
Epithelial	activates	cell_type	0.50
BREAST CANCER	regulates	disease	0.50
Reactive Oxygen Species	regulates	process	0.50
PI3K/AKT/mTOR	associated_with	pathway	0.50
BREAST CANCER	associated_with	disease	0.50
Proteins	associated_with	protein	0.50
SRPK1	interacts_with	concept	0.50
Neuron	activates	cell_type	0.50
HUNTINGTON	co_discussed	disease	0.40
HUNTINGTON'S DISEASE	co_discussed	disease	0.40
MICRORNA REGULATION	regulates	process	0.35
HUNTINGTON	therapeutic_target	disease	0.35
NEURON	activates	cell_type	0.35
NEURON	regulates	cell_type	0.35
PARP1	associated_with	gene	0.35
KEAP1	activates	gene	0.35
NRF2	activates	gene	0.35
NEURON	associated_with	cell_type	0.35
HUNTINGTON	interacts_with	disease	0.35
TP53	inhibits	gene	0.30
PARP1	regulates	gene	0.30

Incoming (546)

Source	Relation	Type	Str
CANCER	inhibits	gene	1.00
Als	therapeutic_target	disease	1.00
Cancer	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	regulates	disease	1.00
Cancer	inhibits	disease	1.00
Als	regulates	disease	1.00
DNA	activates	gene	1.00
P53	inhibits	gene	1.00
Senescence	regulates	disease	1.00
APOPTOSIS	regulates	gene	1.00
DNA	inhibits	gene	1.00
CANCER	regulates	gene	1.00
DNA	associated_with	gene	1.00
DNA	regulates	gene	1.00
CANCER	activates	gene	1.00
CANCER	associated_with	gene	1.00
AUTOPHAGY	regulates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
P53	regulates	gene	1.00
Als	activates	disease	1.00
Circadian Clock	modulates	process	0.95
Circadian Clock	modulates	pathway	0.95
NUCLEAR CGAS	associated_with	protein	0.95
Nad	involved_in	compound	0.95
miR-139-5p	regulates	biomarker	0.95
CGAS	inhibits	protein	0.95
Cancer	associated_with	disease	0.95
Tumor	inhibits	disease	0.95
STAT6	promotes	protein	0.92
PARP1	mediates	gene	0.90
32005289	is activatable in	paper	0.90
TP53	regulates	gene	0.90
PCNA	participates_in	protein	0.90
P53	inhibits	gene	0.90
31358782	modulates	paper	0.90
CGAS	suppresses	protein	0.90
APE2	participates_in	gene	0.90
miR-139-5p	inhibits	biomarker	0.90
P53	regulates	gene	0.90
PARP	involved_in	protein	0.90
DNA	causes	gene	0.90
GENES	therapeutic_target	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
DNA	therapeutic_target	gene	0.90
Tumor	associated_with	disease	0.90
Tumor	therapeutic_target	disease	0.90
Als	associated_with	disease	0.85
CLOCK	modulates	entity	0.85

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Oligodendrocyte DNA Repair Enhancement Therapy	0.665	neurodegeneration	Cell type vulnerability in Alzheimer's D
Oligodendrocyte DNA Repair Enhancement	0.550	neurodegeneration	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Overexpression of the ERG oncogene in prostate cancer identifies candidates for [PMID:41632544]	Köcher S, Elsesy ME, Moustafa A, Mohamma	J Clin Invest	2026
Genetic variations in base excision repair genes and the risk of developing hepa [PMID:41844453]	Shao B, Yin H, Zhang S, He S, Lu H et al	Cancer Genet	2026
Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and [PMID:41889852]	Liu J, Gonzalez-Hunt CP, Richbourg T, Ba	bioRxiv : the preprint server	2026
PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its [PMID:41890038]	Dumoulin I, Lee BJ, Zhang C, Lin X, Wang	bioRxiv	2026
Function of HIF-1α in Regulation of Antioxidative Stress of Tribolium castaneum [PMID:41899005]	Wan Z, Li X, Wang Y, Miao S, Chen Z et a	Insects	2026
Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XR [PMID:41922367]	Dauben H, Mihaljević M, Kolvenbach A, Pa	Nat Commun	2026

Debates (1)

Multi-agent debates referencing this entity

What cell types are most vulnerable in Alzheimer's Disease based on SEA-AD trans

closed · Rounds: 4 · Score: 0.95 · 2026-04-02

Related Research

Hypotheses and analyses mentioning DNA REPAIR in their description or question text

No additional research found