| Gene Symbol | CK2 |
| Aliases | Casein Kinase 2 |
| Function | CK2 exists as a tetrameric holoenzyme composed of two catalytic subunits (α or α') and two regulatory β subunits. The regulatory β subunit enhances substrate specificity, modulates activity, and ta... |
| Subcellular Localization | Targets to compartments |
| Molecular Weight | 44 kDa |
| Pathways | Notch Signaling, blood-brain barrier |
| GeneCards | CK2 |
| Human Protein Atlas | CK2 |
| N-lobe | Contains β-strands and glycine-rich loop |
| C-lobe | α-helical, substrate binding |
| Active site | Deep cleft, unique substrate recognition |
| ATP-binding | Uses both ATP and GTP |
| Substrate targeting | Increases specificity |
| Activity modulation | Can activate or inhibit |
| Assembly | Dimerization core |
| Associated Diseases | ALS, Alzheimer, Huntington's disease |
| Interactions | AQP4, ATP, BRAF, MAPK, MYH9, NPM1 |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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