protein

PP2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PP2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

3Outgoing

6Incoming

0Experiments

0Debates

Summary

Protein Phosphatase 2B (Calcineurin) — calcium/calmodulin-dependent serine/threonine phosphatase critical for synaptic plasticity, learning, and neuronal survival

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🔬 Protein Info

Gene Symbol	PP2B
Aliases	Calcineurin
Function	Calcineurin exists as a heterodimer composed of a catalytic A subunit (approximately 59-64 kDa) and a calcium-binding regulatory B subunit (approximately 19 kDa).
Molecular Weight	59 kDa
Amino Acids	521 aa
Pathways	calcium signaling
GeneCards	PP2B
Human Protein Atlas	PP2B
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	NFAT1, NFAT2
KG Connections	9 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

PP2B Protein (Calcineurin)

protein · 2320 words

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Pathway Diagram

graph TD
    PP2B(["PP2B"])
    style PP2B fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    calcium_signaling(["calcium signaling"])
    T_cells(["T cells"])
    NFAT1(["NFAT1"])
    NFAT2(["NFAT2"])

    PP2B -->|"participates_in"| calcium_signaling
    PP2B -->|"expressed_in"| T_cells
    NFAT1 -->|"activates"| PP2B
    NFAT2 -->|"activates"| PP2B

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class calcium_signaling protein
    class T_cells protein
    class NFAT1 protein
    class NFAT2 protein

Outgoing (3)

Target	Relation	Type	Str
MAPK signaling	participates_in	pathway	0.60
calcium signaling	participates_in	pathway	0.55
T cells	expressed_in	cell_type	0.55

Incoming (6)

Source	Relation	Type	Str
CK2	regulates	gene	0.60
IKK	regulates	gene	0.60
MAPK14	regulates	gene	0.60
PP2A	regulates	gene	0.60
NFAT1	activates	gene	0.55
NFAT2	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PP2B in their description or question text

No additional research found