gene

P2RY13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RY13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

1Hypotheses

0Analyses

9Outgoing

10Incoming

0Experiments

0Debates

Summary

Purinergic Receptor P2Y13 - GPCR involved in microglial phagocytosis, neuroinflammation, and potential therapeutic target for neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	P2RY13
Aliases	Purinergic Receptor P2Y13
Chromosome	3q25.2
Protein Type	Receptor
Function	is a G protein-coupled receptor (GPCR) belonging to the P2Y receptor family that responds to extracellular nucleotides, particularly ATP and ADP.
Primary Expression	immune cells, including microglia in the brain, where it plays a crucial role in modulating inflammatory re
Molecular Weight	42 kDa
Amino Acids	339 aa
Pathways	PI3K, MAPK pathway, NF-κB
Ensembl ID	ENSG00000144647
GeneCards	P2RY13
Human Protein Atlas	P2RY13
Associated Diseases	Atherosclerosis, Cardiovascular, Ms
Interactions	CSF1R, CX3CR1, P2RY12, TMEM119
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

P2RY13

gene · 1111 words

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P2RY13 Protein

protein · 1724 words

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Pathway Diagram

graph TD
    P2RY13["P2RY13"]
    Ms{"Ms"}
    P2RY13 -->|"associated with"| Ms
    Cardiovascular{"Cardiovascular"}
    P2RY13 -->|"associated with"| Cardiovascular
    Atherosclerosis{"Atherosclerosis"}
    P2RY13 -->|"associated with"| Atherosclerosis
    Inflammation{"Inflammation"}
    P2RY13 -->|"contributes to"| Inflammation
    Immune_Response(["Immune Response"])
    P2RY13 -->|"associated with"| Immune_Response
    neurodegeneration["neurodegeneration"]
    P2RY13 -->|"implicated in"| neurodegeneration
    MMP9["MMP9"]
    MMP9 -->|"biomarker for"| P2RY13
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"contributes to"| P2RY13
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| P2RY13
    style P2RY13 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Inflammation	contributes_to	disease	0.65
Immune Response	associated_with	pathway	0.60
CYTOKINES	expressed_in	gene	0.60
App	expressed_in	protein	0.60
ADCY2	regulates	gene	0.60
TMEM119	inhibits	gene	0.55

Incoming (10)

Source	Relation	Type	Str
genes-p2ry13	documents	wiki_page	1.00
genes-p2ry13	describes	wiki_page	1.00
MMP9	biomarker_for	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
GRM1	regulates	gene	0.60
CCR8	regulates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
CSF1R	inhibits	gene	0.55
CX3CR1	inhibits	gene	0.55
P2RY12	inhibits	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
P2RY12/P2RY13 Purinergic Receptor Metabolic Rewiring	0.490	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning P2RY13 in their description or question text

No additional research found