gene 745 words KG: CACNA1A
Contents

CACNA1A — Calcium Channel Alpha-1A Subunit

🧬 Gene Info
Gene SymbolCACNA1A
Full NameCalcium Voltage-Gated Channel Subunit Alpha1 A
AliasesCalcium Channel Alpha-1A Subunit
Chromosome19p13.13
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncerebellar Purkinje cells and hippocampal neurons, where it mediates:
UniProt IDO00555
NCBI Gene ID773
Ensembl IDENSG00000141837
OMIM601011
GeneCardsCACNA1A
Human Protein AtlasCACNA1A
Associated DiseasesAls, Ms
Known Drugs/CompoundsGW201
InteractionsCACNA1C, CACNA1D, CACNA1E, cacna1f, CACNA1F, CACNA1G
KG Connections66 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ATXN2 Gene
gene · KG edge: associated_with
CACNA1C Gene
gene · KG edge: associated_with
CACNA1D Gene
gene · KG edge: associated_with
CACNA1E Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ATXN2 associated_with CACNA1A
CACNA1A associated_with CHAT
CACNA1A associated_with FERMT2
CACNA1A associated_with OPTN
CACNA1A associated_with ABCA1
CACNA1A associated_with DPM2
CACNA1A associated_with TBK1
CHAT associated_with CACNA1A
ABCA1 associated_with CACNA1A
CACNA1A contributes_to CCS

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