gene

DPM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DPM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

4Outgoing

10Incoming

0Experiments

0Debates

Summary

Page for DPM2 Gene (Dolichol-Phosphate Mannosyltransferase Subunit 2)

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🧬 Gene Info

Gene Symbol	DPM2
Aliases	Dolichol-Phosphate Mannosyltransferase Subunit 2
Chromosome	9q34.11
Protein Type	Synthase
Function	The DPM2 gene encodes a regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex[@schenk2001].
Primary Expression	Purkinje cells of cerebellum
Subcellular Localization	DPM2 helps localize the complex to the endoplasmic reticulum membrane
Molecular Weight	40 kDa
UniProt ID	O95477
NCBI Gene ID	8769
Ensembl ID	ENSG00000110693
GeneCards	DPM2
Human Protein Atlas	DPM2
Complex Assembly	DPM2 is essential for proper assembly of the DPM synthase complex
Enzyme Activity	DPM2 modulates the catalytic activity of DPM1
Associated Diseases	Als, Ms
Interactions	DPM1
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DPM2 — AlphaFold O95477 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DPM2 Gene (Dolichol-Phosphate Mannosyltransferase Subunit 2)

gene · 1826 words

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Pathway Diagram

graph TD
    DPM2["DPM2"]
    Als{"Als"}
    DPM2 -->|"associated with"| Als
    Ms{"Ms"}
    DPM2 -->|"associated with"| Ms
    TBK1["TBK1"]
    DPM2 -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    DPM2 -->|"implicated in"| neurodegeneration
    ATXN2["ATXN2"]
    ATXN2 -->|"associated with"| DPM2
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| DPM2
    CHAT["CHAT"]
    CHAT -->|"associated with"| DPM2
    FERMT2["FERMT2"]
    FERMT2 -->|"associated with"| DPM2
    OPTN["OPTN"]
    OPTN -->|"associated with"| DPM2
    GENES["GENES"]
    GENES -->|"associated with"| DPM2
    ABCA1["ABCA1"]
    ABCA1 -->|"associated with"| DPM2
    NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
    NORMAL_TENSION_GLAUCOMA -->|"associated with"| DPM2
    TBK1 -->|"associated with"| DPM2
    style DPM2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
DPM3	stabilizes	gene	0.80
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
TBK1	associated_with	gene	0.60

Incoming (10)

Source	Relation	Type	Str
DPM1	interacts_with	gene	0.90
CACNA1A	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
FERMT2	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
GENES	associated_with	gene	0.60
NORMAL TENSION GLAUCOMA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DPM2 in their description or question text

No additional research found