| Gene Symbol | CALCNA1 |
| Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 A |
| Chromosome | 19p13.2 |
| Function | Synaptic Transmission: P/Q-type channels are the primary voltage-gated calcium channels at presynaptic terminals, triggering neurotransmitter release through their high-affinity calcium binding [@mint |
| Primary Expression | a cell-type specific manner: |
| UniProt ID | [O00555](https://www.uniprot.org/uniprot/O00555) |
| Ensembl ID | ENSG00000141837 |
| GeneCards | CALCNA1 |
| Human Protein Atlas | CALCNA1 |
| Alpha-1A subunit | The pore-forming subunit encoded by CACNA1A |
| Alpha-2/delta subunit | Auxiliary subunit that modulates channel trafficking and function |
| Beta subunit | Auxiliary subunit that regulates channel kinetics |
| Gamma subunit | Auxiliary subunit that influences channel properties |
| Activation | Voltage-dependent opening at membrane potentials around -40 mV |
| Inactivation | Both voltage-dependent and calcium-dependent inactivation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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