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protein 1,129 words KG: JNK
Contents

JNK (c-Jun N-terminal Kinase) Protein

🔬 Protein Info
Gene SymbolJNK
ChromosomeMAPK8: 10q11.22, MAPK9: 5q35.1, MAPK10: 4q21.3
Protein TypeKinase
FunctionUpstream activation: Stress signals (UV radiation, oxidative stress, inflammatory cytokines) activate MAPKKKs such as MEKK1, MLK3, and TAK1
Molecular Weight~46-48 kDa per isoform
PathwaysAkt, Apoptosis, Autophagy, Differentiation, Ferroptosis
GeneCardsJNK
Human Protein AtlasJNK
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsANTHOCYANINS, NAC, N-ACETYLCYSTEINE, Palmitic Acid, Quercetin, rapamycin
Interactions6-OHDA, ABCD3, ACC, AD, AGING, AIM2
KG Connections2244 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (42)

Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56Blood-Brain Barrier SPM Shuttle System
Score: 0.53Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75Circadian-Synchronized Proteostasis Enhancement
Score: 0.74Smartphone-Detected Motor Variability Correction
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72Retinal Vascular Microcirculation Rescue
Score: 0.72Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Membrane Cholesterol Gradient Modulators
Score: 0.71Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Ocular Immune Privilege Extension
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69Flotillin-1 Stabilization Compounds
Score: 0.68Digital Twin-Guided Metabolic Reprogramming
Score: 0.55Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
← Prevpg 2/3Next →

Related Analyses (14)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (9)

acc-chronic-pain
cell_type · KG edge: activatesABCD3 Gene
gene · KG edge: interacts_withABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_targetAIF Gene
gene · KG edge: regulatesAKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

HSPA1A regulates JNK
JNK activates c_Jun
JUN regulates JNK
JNK activates RB1CC1 nuclear translocation
DDIT3 activates JNK
DISC1 activates JNK
JNK regulates neurodegeneration
JNK regulates gliosis
MTOR regulates JNK
MTOR activates JNK

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