| Gene Symbol | JNK |
| Chromosome | MAPK8: 10q11.22, MAPK9: 5q35.1, MAPK10: 4q21.3 |
| Protein Type | Kinase |
| Function | Upstream activation: Stress signals (UV radiation, oxidative stress, inflammatory cytokines) activate MAPKKKs such as MEKK1, MLK3, and TAK1 |
| Molecular Weight | ~46-48 kDa per isoform |
| Pathways | Akt, Apoptosis, Autophagy, Differentiation, Ferroptosis |
| GeneCards | JNK |
| Human Protein Atlas | JNK |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | ANTHOCYANINS, NAC, N-ACETYLCYSTEINE, Palmitic Acid, Quercetin, rapamycin |
| Interactions | 6-OHDA, ABCD3, ACC, AD, AGING, AIM2 |
| KG Connections | 2244 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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