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protein 1,129 words KG: JNK
Contents

JNK (c-Jun N-terminal Kinase) Protein

🔬 Protein Info
Gene SymbolJNK
ChromosomeMAPK8: 10q11.22, MAPK9: 5q35.1, MAPK10: 4q21.3
Protein TypeKinase
FunctionUpstream activation: Stress signals (UV radiation, oxidative stress, inflammatory cytokines) activate MAPKKKs such as MEKK1, MLK3, and TAK1
Molecular Weight~46-48 kDa per isoform
PathwaysAkt, Apoptosis, Autophagy, Differentiation, Ferroptosis
GeneCardsJNK
Human Protein AtlasJNK
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsANTHOCYANINS, NAC, N-ACETYLCYSTEINE, Palmitic Acid, Quercetin, rapamycin
Interactions6-OHDA, ABCD3, ACC, AD, AGING, AIM2
KG Connections2244 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (42)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Multi-Modal Stress Response Harmonization
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75Phase-Separated Organelle Targeting
Score: 0.73Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69RNA Granule Nucleation Site Modulation
Score: 0.66Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60
pg 1/3Next →

Related Analyses (14)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (9)

acc-chronic-pain
cell_type · KG edge: activatesABCD3 Gene
gene · KG edge: interacts_withABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_targetAIF Gene
gene · KG edge: regulatesAKT1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

HSPA1A regulates JNK
JNK activates c_Jun
JUN regulates JNK
JNK activates RB1CC1 nuclear translocation
DDIT3 activates JNK
DISC1 activates JNK
JNK regulates neurodegeneration
JNK regulates gliosis
MTOR regulates JNK
MTOR activates JNK

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