gene 729 words KG: CAT
Contents

CAT — Catalase

🧬 Gene Info
Gene SymbolCAT
Full NameCatalase
Chromosome11
Protein TypeEnzyme
FunctionCatalase is a tetrameric heme-containing enzyme that functions as one of the primary antioxidant defenses in cells.
Primary Expressionperoxisomes (primary location), cytosol and mitochondria, with highest levels in liver, kidney, and brain
Subcellular Localization**: Peroxisomes
PathwaysAkt, Apoptosis, Autophagy, Epigenetic, Ferroptosis
UniProt IDP04040
NCBI Gene ID847
Ensembl IDENSG00000121691
OMIM115500
GeneCardsCAT
Human Protein AtlasCAT
Associated DiseasesAD, ADH, Aging, ALI, Als
Known Drugs/Compoundsrapamycin
InteractionsABCD3, ABCG2, ACTB, Actin, AD, AKT
KG Connections1468 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (26)

Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Quantum Coherence Disruption in Cellular Communication
Score: 0.63

Related Analyses (9)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

Related Experiments (4)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: activates
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: debate_co_mention
ACTB Gene
gene · KG edge: inhibits
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed

Knowledge Graph (12 edges)

ACTB regulates CAT
PPARA regulates CAT
CAT regulates SQSTM1
CAT regulates RPS6KB1
CAT regulates RAB7A
CAT regulates SREBF1
CAT regulates EIF4EBP1
CAT regulates CTSD
CAT regulates PPARGC1A
CAT regulates LRP2

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