Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MIR-34A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MIR-34A |
| Key Genes/Proteins | ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, ATF3, BAX |
| Related Diseases | ALS, Alzheimer, Huntington |
| Related Pathways | Apoptosis |
graph TD
MIR_34A["MIR-34A"]
MIR_34A -->|"inhibits"| SIRT1["SIRT1"]
NF_kB["NF-kB"] -->|"regulates"| MIR_34A
urolithin_A["urolithin A"] -->|"inhibits"| MIR_34A
GENES["GENES"] -->|"interacts"| MIR_34A
NDUFA9["NDUFA9"] -->|"interacts"| MIR_34A
HIP1["HIP1"] -->|"interacts"| MIR_34A
AND["AND"] -->|"interacts"| MIR_34A
TGM2["TGM2"] -->|"interacts"| MIR_34A
NRF1["NRF1"] -->|"interacts"| MIR_34A| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | exacerbates | process | 0.80 |
| SIRT1 | inhibits | gene | 0.70 |
| Huntington | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Apoptosis | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NF-kB | regulates | protein | 0.80 |
| urolithin A | inhibits | chemical | 0.70 |
| HDAC2 | targets | gene | 0.70 |
| HIP1 | interacts_with | gene | 0.60 |
| HUNTINGTON'S DISEASE | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| TGM2 | interacts_with | gene | 0.60 |
| NRF1 | interacts_with | gene | 0.60 |
| MIRNAS | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| NFKB1 | associated_with | gene | 0.60 |
| HSA-MIR-181A-5P | interacts_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| IL-18 | associated_with | gene | 0.60 |
| ATF3 | associated_with | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| BAX | associated_with | gene | 0.60 |
| NR3C1 | associated_with | gene | 0.60 |
| CASP3 | associated_with | gene | 0.60 |
| PTGS2 | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| NDUFA9 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MIR-34A in their description or question text
No additional research found