gene

HIP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections
1Hypotheses
0Analyses
12Outgoing
6Incoming
0Experiments
0Debates

Summary

Page for HIP1 Gene

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🧬 Gene Info
Gene SymbolHIP1
Protein TypeScaffold Protein
Functionis a protein encoded by the HIP1 gene.
Subcellular Localization**Synaptic vesicles**: Concentrated in presynaptic terminals
Molecular Weight116 kDa
Amino Acids3685 aa
UniProt IDQ9Y4X5
GeneCardsHIP1
Human Protein AtlasHIP1
Associated Diseasesneurodegeneration
InteractionsGENES, HUNTINGTON, HUNTINGTON'S DISEASE, MIR-34A, MIRNAS, NDUFA9
KG Connections18 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: HIP1 — AlphaFold Q9Y4X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

HIP1 Gene

gene · 1107 words

HIP1R (Huntingtin Interacting Protein 1-Related)

gene · 2170 words

INPP5D — Inositol Polyphosphate-5-Phosphatase D (SHIP1)

gene · 1933 words

INPP5D SHIP1 Dysfunction Alzheimer's Disease Causal Chain

mechanism · 1097 words

SHIP1 (INPP5D) Protein

protein · 896 words

HIP1 Protein

protein · 655 words

Pathway Diagram

flowchart TD
    N0["HIP1"]
    N1["Huntington"]
    N0 -->|"therapeutic target"| N1
    N0 -->|"interacts with"| N1
    N2["MIRNAS"]
    N0 -->|"therapeutic target"| N2
    N3["HUNTINGTON'S DISEASE"]
    N0 -->|"interacts with"| N3
    N4["HUNTINGTON"]
    N0 -->|"interacts with"| N4
    N5["AND"]
    N0 -->|"interacts with"| N5
    N6["TGM2"]
    N0 -->|"interacts with"| N6
    N7["NRF1"]
    N0 -->|"interacts with"| N7
    N0 -->|"interacts with"| N2
    N8["MIR-34A"]
    N0 -->|"interacts with"| N8
    N9["NDUFA9"]
    N0 -->|"interacts with"| N9
    N0 -->|"therapeutic target"| N4
    N10["Actin"]
    N0 -->|"therapeutic target"| N10
    N7 -->|"interacts with"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 protein

Outgoing (12)

TargetRelationTypeStr
Huntingtontherapeutic_targetdisease0.65
Huntingtoninteracts_withdisease0.65
HUNTINGTON'S DISEASEinteracts_withgene0.60
HUNTINGTONinteracts_withgene0.60
MIRNASinteracts_withgene0.60

Incoming (6)

SourceRelationTypeStr
HUNTINGTONtherapeutic_targetgene0.60
GENESinteracts_withgene0.60
MIRNAStherapeutic_targetgene0.60
NRF1interacts_withgene0.60
NDUFA9interacts_withgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
INPP5D (SHIP1) Inhibition to Shift Microglial Polarization 0.758 neurodegeneration TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] Tsai AP, Martin AK, Mi A, Yeh AE, Ramire Molecular neurodegeneration 2026 0
Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850] Xu Z, Chen M, Liang F, Song S, Lei J et J Transl Med 2026 0
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359] Xie X, Liu J, Liang W, Zhang Y, Gong X e Immunity 2026 0
INPP5D/SHIP1-mediated immunometabolic remodeling of renal monocytes in idiopathi [PMID:41853261] Dai H, Liu B, Rui H, Yang L, Jiang H et Front Immunol 2026 0
PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] Tsai AP, Martin AK, Mi A, Yeh AE, Ramire Mol Neurodegener 2026 0
SHIP-1 adapter functions mediate recruitment of FCRL1 to the BCR and inhibition [PMID:41968726] Wolfe MM, Tallon Arranz R, Zenni EL, Wil Immunohorizons 2026 0
Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359] Xie X, Liu J, Liang W, Zhang Y, Gong X, Immunity 2026 0
Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850] Xu Z, Chen M, Liang F, Song S, Lei J, Hu Journal of translational medic 2026 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HIP1 in their description or question text

No additional research found