Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HIP1 |
| Protein Type | Scaffold Protein |
| Function | is a protein encoded by the HIP1 gene. |
| Subcellular Localization | **Synaptic vesicles**: Concentrated in presynaptic terminals |
| Molecular Weight | 116 kDa |
| Amino Acids | 3685 aa |
| UniProt ID | Q9Y4X5 |
| GeneCards | HIP1 |
| Human Protein Atlas | HIP1 |
| Associated Diseases | neurodegeneration |
| Interactions | GENES, HUNTINGTON, HUNTINGTON'S DISEASE, MIR-34A, MIRNAS, NDUFA9 |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["HIP1"]
N1["Huntington"]
N0 -->|"therapeutic target"| N1
N0 -->|"interacts with"| N1
N2["MIRNAS"]
N0 -->|"therapeutic target"| N2
N3["HUNTINGTON'S DISEASE"]
N0 -->|"interacts with"| N3
N4["HUNTINGTON"]
N0 -->|"interacts with"| N4
N5["AND"]
N0 -->|"interacts with"| N5
N6["TGM2"]
N0 -->|"interacts with"| N6
N7["NRF1"]
N0 -->|"interacts with"| N7
N0 -->|"interacts with"| N2
N8["MIR-34A"]
N0 -->|"interacts with"| N8
N9["NDUFA9"]
N0 -->|"interacts with"| N9
N0 -->|"therapeutic target"| N4
N10["Actin"]
N0 -->|"therapeutic target"| N10
N7 -->|"interacts with"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 gene
class N10 protein| Target | Relation | Type | Str |
|---|---|---|---|
| Huntington | therapeutic_target | disease | 0.65 |
| Huntington | interacts_with | disease | 0.65 |
| HUNTINGTON'S DISEASE | interacts_with | gene | 0.60 |
| HUNTINGTON | interacts_with | gene | 0.60 |
| MIRNAS | interacts_with | gene | 0.60 |
| MIR-34A | interacts_with | gene | 0.60 |
| MIRNAS | therapeutic_target | gene | 0.60 |
| HUNTINGTON | therapeutic_target | gene | 0.60 |
| Actin | therapeutic_target | protein | 0.60 |
| TGM2 | interacts_with | gene | 0.60 |
| NRF1 | interacts_with | gene | 0.60 |
| NDUFA9 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| INPP5D (SHIP1) Inhibition to Shift Microglial Polarization | 0.758 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850] | Xu Z, Chen M, Liang F, Song S, Lei J et | J Transl Med | 2026 | 0 |
| Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359] | Xie X, Liu J, Liang W, Zhang Y, Gong X e | Immunity | 2026 | 0 |
| INPP5D/SHIP1-mediated immunometabolic remodeling of renal monocytes in idiopathi [PMID:41853261] | Dai H, Liu B, Rui H, Yang L, Jiang H et | Front Immunol | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Mol Neurodegener | 2026 | 0 |
| SHIP-1 adapter functions mediate recruitment of FCRL1 to the BCR and inhibition [PMID:41968726] | Wolfe MM, Tallon Arranz R, Zenni EL, Wil | Immunohorizons | 2026 | 0 |
| Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359] | Xie X, Liu J, Liang W, Zhang Y, Gong X, | Immunity | 2026 | 0 |
| Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850] | Xu Z, Chen M, Liang F, Song S, Lei J, Hu | Journal of translational medic | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HIP1 in their description or question text
No additional research found