Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | HG |
| Key Genes/Proteins | AKT, ATG7, BAX/BCL2, CD163, EGFR, ERK1 |
| Related Diseases | diabetes |
| Related Pathways | apoptosis pathway, autophagy pathway |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
HG[HG]
HG -->|activates| BAX_BCL2[BAX/BCL2]
HG -->|expressed in| endothelial_cells[endothelial cells]
HG -->|activates| PI3K[PI3K]
HG -->|activates| TLR4[TLR4]
HG -->|activates| TNF[TNF]
HG -->|inhibits| JNK[JNK]
HG -->|inhibits| LC3[LC3]
HG -->|inhibits| SIRT1[SIRT1]
AKT[AKT] -->|activates| HG
EGFR[EGFR] -->|regulates| HG
ERK1[ERK1] -->|regulates| HG
FNDC5[FNDC5] -->|expressed in| HG
HDAC3[HDAC3] -->|inhibits| HG
ATG7[ATG7] -->|inhibits| HG
quercetin[quercetin] -->|targets| HG
CD163[CD163] -->|activates| HG
metformin[metformin] -->|targets| HG| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:HG | data_in | dataset_row | 0.00 |
| BAX/BCL2 | activates | gene | 0.90 |
| endothelial cells | expressed_in | cell_type | 0.70 |
| Wnt signaling | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| diabetes | regulates | disease | 0.60 |
| diabetes | expressed_in | disease | 0.60 |
| mitochondrial function | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| YAP | regulates | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| YAP | cleaves | gene | 0.60 |
| YAP | protects_against | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| TFEB | expressed_in | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| PI3K | activates | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| JNK | inhibits | gene | 0.60 |
| LC3 | inhibits | gene | 0.60 |
| SIRT1 | inhibits | gene | 0.60 |
| JNK | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| IFNAR1 | activates | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| TREM2 | activates | gene | 0.60 |
| TYROBP | activates | gene | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:HG | data_in | dataset_row | 0.00 |
| HDAC3 | inhibits | gene | 0.60 |
| ATG7 | inhibits | gene | 0.60 |
| CD163 | activates | gene | 0.60 |
| EGFR | regulates | gene | 0.60 |
| ERK1 | regulates | gene | 0.60 |
| FNDC5 | expressed_in | gene | 0.60 |
| FNDC5 | activates | gene | 0.60 |
| metformin | targets | drug | 0.60 |
| AKT | activates | gene | 0.60 |
| quercetin | targets | drug | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TDP-43 Pathology Disrupts the HGS-PYGB Autophagy Receptor Ca | 0.678 | neurodegeneration | What mechanisms underlie neuronal resist |
| α-Ketoglutarate/2-HG Metabolic-Epigenetic Window in Neurons | 0.443 | neurodegeneration | What is the optimal therapeutic window d |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HG in their description or question text
No additional research found