| Gene Symbol | ARHGEF6 |
| Full Name | Rho Guanine Nucleotide Exchange Factor 6 |
| Aliases | Rho Guanine Nucleotide Exchange Factor 6 / alpha-PIX |
| Chromosome | Xq26.3 |
| Function | is a Rho family guanine nucleotide exchange factor (GEF) that activates Rho GTPases including Rac1, Cdc42, and RhoA. |
| Primary Expression | Brain (hippocampus, cortex, cerebellum), testis, lung |
| Molecular Weight | 87 kDa |
| Amino Acids | 759 aa |
| UniProt ID | [Q9Y5M8](https://www.uniprot.org/uniprotkb/Q9Y5M8/entry) |
| Ensembl ID | ENSG00000129654 |
| GeneCards | ARHGEF6 |
| Human Protein Atlas | ARHGEF6 |
| Substrate Specificity | Prefers Rac1 over RhoA; shows moderate activity toward Cdc42 |
| Catalytic Mechanism | Promotes GDP release and GTP binding to activate Rac1/Cdc42 |
| Regulation | Activity modulated by binding to PAK (p21-activated kinase), PIXIP, and post-translational modifications |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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