| Gene Symbol | ARHGEF2 |
| Full Name | Rho Guanine Nucleotide Exchange Factor 2 |
| Chromosome | 1q22 |
| Function | ARHGEF2 encodes a Rho GEF that activates Rho GTPases, primarily RhoA, but also Rac1 and Cdc42. |
| Molecular Weight | 220 kDa |
| Amino Acids | 736 aa |
| Exons | 33 |
| UniProt ID | Q9Y5S5 |
| NCBI Gene ID | 9199 |
| Ensembl ID | ENSG00000116584 |
| OMIM | 607560 |
| GeneCards | ARHGEF2 |
| Human Protein Atlas | ARHGEF2 |
| ROCK (Rho-associated kinase) | Phosphorylates myosin light chain (MLC), enhancing contractility |
| Dendritic spine morphology | High ROCK activity promotes spine shrinkage/retraction |
| Associated Diseases | Intellectual disability, Midbrain-hindbrain malformation |
| Interactions | AMPK, CaMKK2, Fus, IRF2BP2, LMNA, NPM1 |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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