| Gene Symbol | ARHGEF28 |
| Full Name | Rho Guanine Nucleotide Exchange Factor 28 |
| Chromosome | 2p16.3 |
| Function | encodes a Rho guanine nucleotide exchange factor (RhoGEF) that activates Rho family GTPases by catalyzing the exchange of GDP for GTP. |
| Primary Expression | neuronal tissues and plays important roles in synaptic function, neuronal development, and potentially in neurodegenerative disease pathogenesis |
| UniProt ID | [Q9Y5R5](https://www.uniprot.org/uniprot/Q9Y5R5) |
| Ensembl ID | ENSG00000136541 |
| GeneCards | ARHGEF28 |
| Human Protein Atlas | ARHGEF28 |
| RhoA Activation | ARHGEF28 activates RhoA, leading to downstream effects on actin cytoskeleton, myosin light chain phosphorylation, and cellular contractility. |
| Synaptic Signaling | Rho GTPases regulate synaptic structure and function; GEFs like ARHGEF28 link synaptic activity to cytoskeletal changes. |
| Dendritic Spine Regulation | Rho GTPase signaling controls spine morphology and plasticity through actin dynamics. |
| Axon Guidance | RhoGEFs direct growth cone collapse and turning in response to guidance cues. |
| Actin Polymerization | RhoA activation leads to actin stress fiber formation and contractility. |
| Cell Morphology | Changes in cell shape require coordinated Rho GTPase activation by GEFs. |
| Associated Diseases | Alzheimer's disease:[@koh2019][@xu2018], ALS:[@rikitake2020], schizophrenia risk |
| Databases | GeneCardsNCBI GeneHPASTRING |
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