| Gene Symbol | ARHGEF6 |
| Full Name | Rho Guanine Nucleotide Exchange Factor 6 |
| Aliases | Rho Guanine Nucleotide Exchange Factor 6 / alpha-PIX |
| Chromosome | Xq26.3 |
| Function | is a Rho family guanine nucleotide exchange factor (GEF) that activates Rho GTPases including Rac1, Cdc42, and RhoA. |
| Primary Expression | Brain (hippocampus, cortex, cerebellum), testis, lung |
| Subcellular Localization | </th><td>Cytoplasm, membrane, dendritic spines</td></tr> |
| Molecular Weight | 87 kDa |
| Amino Acids | 759 aa |
| UniProt ID | [Q9Y5M8](https://www.uniprot.org/uniprotkb/Q9Y5M8/entry) |
| Ensembl ID | ENSG00000129654 |
| GeneCards | ARHGEF6 |
| Human Protein Atlas | ARHGEF6 |
| SH3 domain (N-terminal) | Proline-rich regions that mediate protein-protein interactions |
| Dbl homology (DH) domain | Catalytic domain that activates Rho GTPases |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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