| Gene Symbol | ARHGEF7 |
| Full Name | Rho Guanine Nucleotide Exchange Factor 7 |
| Chromosome | 13q14.3 |
| Function | This domain adopts a Dbl-like fold that facilitates the conformational changes required for GDP release and GTP binding. |
| Primary Expression | the brain, particularly in the cerebral cortex and hippocampus, where it localizes to [dendriti |
| Amino Acids | 803 aa |
| Ensembl ID | ENSG00000150760 |
| GeneCards | ARHGEF7 |
| Human Protein Atlas | ARHGEF7 |
| N-terminal SH3 Domain | Mediates interaction with proline-rich regions of target proteins, including PAKs and other signaling molecules |
| Dbl Homology (DH) Domain | The catalytic core that catalyzes GDP/GTP exchange on Rho GTPases |
| PH Domain (Pleckstrin Homology) | Involved in membrane localization and protein-lipid interactions |
| C-terminal PDZ Domain | Facilitates interaction with PDZ-domain containing proteins and contributes to scaffolding functions |
| Associated Diseases | Als |
| Interactions | AUTOPHAGY, CDC42, LRRK2, MAPK, NEURON, PARKINSON |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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