| Gene Symbol | TREH |
| Full Name | Trehalase |
| Chromosome | 11q23.3 |
| Function | is a non-reducing disaccharide found in many organisms, where it serves as a protectant against various environmental stresses. |
| Primary Expression | the small intestine, kidney, liver, and brain |
| Subcellular Localization | the cytosol |
| Molecular Weight | 65 kDa |
| Amino Acids | 583 aa |
| Pathways | Autophagy, Chaperone, Tdp-43, autophagy pathway, oxidative stress response |
| UniProt ID | [Q9NUH0](https://www.uniprot.org/uniprot/Q9NUH0) |
| Ensembl ID | ENSG00000143537 |
| GeneCards | TREH |
| Human Protein Atlas | TREH |
| Membrane-bound trehalase | Attached to cell membranes via transmembrane domain |
| Soluble trehalase | Secreted or cytosolic localization |
| Associated Diseases | Als, Amyotrophic Lateral Sclerosis, Ataxia, disease, Huntington, Neuroblastoma |
| Known Drugs/Compounds | rapamycin |
| Interactions | amyotrophic lateral sclerosis, AR, ATG, ATG10, ATG12, AUTOPHAGY |
| KG Connections | 179 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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