gene 503 words KG: TLR7
Contents

TLR7 Gene

🧬 Gene Info
Gene SymbolTLR7
Full NameToll-Like Receptor 7
ChromosomeXp22.2
FunctionTLR7 is a type I transmembrane protein localized primarily in endosomal compartments:
Molecular Weight120 kDa
PathwaysNF-κB
UniProt IDQ9NYK5
NCBI Gene ID51284
Ensembl IDENSG00000196664
OMIM300365
GeneCardsTLR7
Human Protein AtlasTLR7
Extracellular domainLeucine-rich repeats (LRRs) for nucleic acid recognition
Transmembrane domainSingle pass membrane protein
TIR domainIntracellular signaling domain
Associated DiseasesInflammation, Ms
InteractionsACTB, AND, ATG16L1, AUTOPHAGY, BRAIN INFLAMMATION, CAT
KG Connections121 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: contributes_to
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: therapeutic_target
Genes
index · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: interacts_with
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: activates

Knowledge Graph (12 edges)

ERN1 biomarker_for TLR7
TLR7 biomarker_for PPARGC1A
TLR7 biomarker_for MYC
TLR7 biomarker_for SLC11A1
CD4 interacts_with TLR7
MAPK3 interacts_with TLR7
ZAP70 interacts_with TLR7
TP53 interacts_with TLR7
CD19 interacts_with TLR7
EEF2 interacts_with TLR7

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