gene 2,871 words KG: TERT
Contents

TERT Gene

🧬 Gene Info
Gene SymbolTERT
Full NameTelomerase Reverse Transcriptase
Chromosome5p15.33
Functiondyskerin (DKC1): Stabilizes the complex
Primary Expressionhippocampal subgranular zone (SGZ)
Molecular Weight127 kDa
Amino Acids1132 aa
Exons16
PathwaysTelomere Dysfunction
UniProt ID[O14748](https://www.uniprot.org/uniprot/O14748)
Ensembl IDENSG00000164362
OMIM607409
GeneCardsTERT
Human Protein AtlasTERT
Reverse transcriptase activityCatalyzes addition of TTAGGG repeats to telomeres
Associated DiseasesAD, ALI, Als, AMI, cancer
Known Drugs/CompoundsTAC
InteractionsACVR2A, AGING, AKT, AKT3, AMPK, AND
KG Connections525 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (37)

Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
← Prevpg 2/2

Related Analyses (19)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (14)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ACVR2A Gene
gene · KG edge: activates
ALDH1A1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

IDH1 therapeutic_target TERT
VEGFA therapeutic_target TERT
MDM4 therapeutic_target TERT
APOB therapeutic_target TERT
SF3B1 therapeutic_target TERT
MET therapeutic_target TERT
SMARCA4 therapeutic_target TERT
TERT therapeutic_target JUN
TERT therapeutic_target EEF1A1
TERT therapeutic_target MCL1

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