| Gene Symbol | SPG7 |
| Full Name | Spastic Paraplegia 7 (Paraplegin) |
| Chromosome | 16q24.3 |
| Protein Type | Gene |
| Function | is a gene located on chromosome 16q24. |
| Molecular Weight | 88 kDa |
| Amino Acids | 795 aa |
| Exons | 16 |
| GeneCards | SPG7 |
| Human Protein Atlas | SPG7 |
| N-terminal transmembrane domain | Anchors the protein to the inner mitochondrial membrane with a single transmembrane helix (residues 1-64). |
| Zinc-binding domain | The proteolytic active sites coordinate zinc ions for protein degradation activity. |
| Associated Diseases | Als, Alzheimer, demyelination, Ms, neurodegeneration |
| Interactions | BECN1, BNIP3, BNIP3L, CEBPB, DDIT3, DNM1L |
| KG Connections | 100 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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