gene 972 words KG: ACE
Contents

ACE Gene

🧬 Gene Info
Gene SymbolACE
Full NameAngiotensin Converting Enzyme
AliasesACE1, CD143, DCP1
Chromosome17q23.3
Protein TypeProtease
FunctionConverts angiotensin I to angiotensin II
Molecular Weight149.7 kDa
Amino Acids1306
PathwaysRenin-angiotensin system, Bradykinin metabolism
UniProt IDP12821
NCBI Gene ID1636
Ensembl IDENSG00000159640
OMIM106180
GeneCardsACE
Human Protein AtlasACE
Associated DiseasesAls, Alzheimer, Alzheimer's disease, cancer, Cardiac
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND, APOPTOSIS
SciDEX HypothesesMicroglial ACE Enhancement for Amyloid Clearance
KG Connections335 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (17)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · completed
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (5)

Plasma ATN biomarkers across AD continuum in Chilean cohort
clinical · proposed · Score: 0.95
Intensive Medical Treatment vs Usual Care in Women with ANOC
clinical · proposed · Score: 0.95
ACEs and Motoric Cognitive Risk Syndrome in Chinese Older Ad
clinical · proposed · Score: 0.95
Preinjury ACE-I/ARB exposure and outcomes in transfused trau
clinical · proposed · Score: 0.95
N-of-1 Clinical Trial Design for CBS/PSP
clinical · proposed · Score: 0.40

See Also (15)

BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 6 hypotheses
adam17
gene · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

ACE activates TNF
ACE therapeutic_target TREM2
ACE therapeutic_target PILRA
ACE therapeutic_target IDUA
ACE therapeutic_target TAU
ACE therapeutic_target GRN
ACE expressed_in NDUFS8
ACE expressed_in LDLR
ACE expressed_in CLU
ACE expressed_in SPG7

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