gene 891 words KG: AXIN2
Contents

AXIN2 Gene

🧬 Gene Info
Gene SymbolAXIN2
Chromosome17q24.1
Protein TypeGene
Functionis a critical negative regulator of the Wnt/beta-catenin signaling pathway.
Primary Expressionneural stem cells (NSCs) in the adult subventricular zone (SVZ) and dentate gyrus subgranular zone (SGZ):
Molecular Weight88 kDa
Amino Acids778 aa
PathwaysWnt, Wnt signaling, Wnt pathway
UniProt IDQ9Y2T1
NCBI Gene ID8313
Ensembl IDENSG00000168646
GeneCardsAXIN2
Human Protein AtlasAXIN2
Associated DiseasesCancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsAMPK, ATG, BECN1, CCND1, CYCLIN D1, FAM83A
KG Connections237 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.88
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (8)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: therapeutic_target
ALDH1A1 Gene
gene · KG edge: therapeutic_target
APC Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TCF4 associated_with AXIN2
MYC associated_with AXIN2
LC3 associated_with AXIN2
MTOR associated_with AXIN2
BECN1 associated_with AXIN2
CTNNB1 associated_with AXIN2
AXIN2 associated_with GAPDH
AXIN2 associated_with SQSTM1
AXIN2 associated_with RAB7A
AXIN2 associated_with LAMP1

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