gene 1,715 words KG: MRC1
Contents

MRC1 — Mannose Receptor C Type 1

🧬 Gene Info
Gene SymbolMRC1
Full NameMannose Receptor C Type 1 (CD206)
AliasesCD206
Chromosome10p12.33
Protein TypeReceptor
Functionencodes a C-type lectin receptor that plays a critical role in immune recognition and clearance of glycoproteins.
Molecular Weight175 kDa
Amino Acids1456 aa
Exons30
PathwaysImmune Response
UniProt ID[P22897](https://www.uniprot.org/uniprot/P22897)
Ensembl IDENSG00000138739
GeneCardsMRC1
Human Protein AtlasMRC1
Associated DiseasesAls, Cirrhosis, Fibrosis
InteractionsCANCER, CD14, CD200, CD200R1, ICAM1, IL10
KG Connections103 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

TREM2-Dependent Microglial Senescence Transition
Score: 0.95
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: regulates
Genes
index · KG edge: associated_with
C1QB — Complement Component 1Q Beta
gene · KG edge: regulates
CASP1 Gene
gene · KG edge: associated_with
CCR1
gene · KG edge: regulates

Knowledge Graph (12 edges)

ICAM1 activates MRC1
TREM2 expressed_in MRC1
TLR2 activates MRC1
NFKBIA activates MRC1
MRC1 expressed_in IL1B
MRC1 activates ITGAM
MRC1 expressed_in TNF
MRC1 expressed_in CXCL2
MRC1 activates CD14
MRC1 expressed_in PPARG

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