gene 2,349 words KG: CD14
Contents

CD14 — CD14 Molecule

🧬 Gene Info
Gene SymbolCD14
Full NameCD14 Molecule
Chromosome5q31.3
Protein TypeReceptor
FunctionIts primary roles include
Primary ExpressionMonocytes, Macrophages, Neutrophils, Microglia
Molecular Weight40 kDa
Amino Acids382 aa
PathwaysAmyloid, Calcium Signaling, Hedgehog, Nf-Κb, Phagocytosis
UniProt IDP08571
NCBI Gene ID929
Ensembl IDENSG00000144891
OMIM158120
GeneCardsCD14
Human Protein AtlasCD14
Associated DiseasesAls, Alzheimer, Atherosclerosis, Carcinoma, Cardiomyopathy
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXA2
KG Connections373 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (10)

Astrocytes
cell · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
ANXA2 — Annexin A2
gene · KG edge: activates
ATF3 Gene
gene · KG edge: activates
BCS1L Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CD163 associated_with CD14
MMP9 biomarker_for CD14
CD14 associated_with CD68
CD14 biomarker_for MMP2
CD47 associated_with CD14
TLR2 associated_with CD14
CD36 associated_with CD14
CMKLR1 interacts_with CD14
RAGE interacts_with CD14
TLR4 associated_with CD14

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