Contents

IL1B Gene - Interleukin 1 Beta

🧬 Gene Info

Gene Symbol	IL1B
Full Name	Interleukin 1 Beta
Chromosome	2q14.1
Protein Type	Ligand
Target Class	Ligand
Function	IL-1 receptor antagonist or neutralizing monoclonal antibody
Mechanism of Action	IL-1 receptor antagonist or neutralizing monoclonal antibody
Druggability	Medium (0.49)
Clinical Stage	Approved
Molecular Weight	31 kDa
Amino Acids	269 aa
Exons	7
Pathways	Akt, Apoptosis, Epigenetic, Mapk, Oxidative Stress
UniProt ID	O43645
NCBI Gene ID	3553
Ensembl ID	ENSG00000125538
OMIM	164520
GeneCards	IL1B
Human Protein Atlas	IL1B
Associated Diseases	AD, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	ANTHOCYANINS, berberine, Berberine, Guhan Yangsheng Jing, rapamycin, resveratrol
Interactions	A2M, ACACA, ACHE, ACTB, Actin, ADAM17
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Peripheral-to-Central Inflammation Circuit Breaker
KG Connections	1918 knowledge graph edges
Databases	GeneCards HPA STRING

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Knowledge Graph

NLRP3 interacts_with IL1B

CASP1 interacts_with IL1B

IL1B interacts_with NLRP3

IL1B interacts_with CASP1

IL1B interacts_with PYCARD

PYCARD interacts_with IL1B

MMP9 co_discussed IL1B

SLC7A11 co_discussed IL1B

CGAS co_discussed IL1B