| Gene Symbol | CD200R1 |
| Aliases | CD200 Receptor 1 |
| Chromosome | 3q13.2 |
| Function | encodes a type I transmembrane protein with extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail containing multiple motifs that mediate inhibitory signaling. |
| Molecular Weight | 50 kDa |
| Amino Acids | 436 aa |
| Ensembl ID | ENSG00000163508 |
| GeneCards | CD200R1 |
| Human Protein Atlas | CD200R1 |
| PI3K/Akt pathway modulation | The receptor can activate PI3K signaling that promotes cell survival and anti-inflammatory phenotypes |
| MAPK pathway inhibition | CD200R1 signaling dampens ERK and p38 MAPK activation in response to inflammatory stimuli |
| NF-κB suppression | The receptor inhibits NF-κB nuclear translocation and transcriptional activity |
| STAT signaling | CD200R1 can influence STAT1 and STAT3 phosphorylation states |
| Associated Diseases | Parkinson, neurodegeneration |
| Interactions | CD200, IL10, MICROGLIA, MRC1, TGFB1 |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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